For example, the overexpression of genes CENPW, MYBL2, and SKA1 is associated with poor prognosis in HCC, while the loss of gene HSD11B1 indicates poor prognosis in HCC (Frau et al., 2011; Chen et al., 2018; Zhou et al., 2020). The gene discussed is HSD11B1; the disease is hepatocellular carcinoma.