HFE and glioblastoma: Biological pathways analyses also established that several common proteins for GBM cell line and proteins only expressed by U87 (Figure 3) are involved in immune regulation processes such as negative regulation of CD8-positive, alpha-beta T cell activation (hfe), negative regulation of activated T cell proliferation (pdcd11g2, cd274) or negative regulation of interferon-gamma production (c1qbp).