IL18 and polycystic ovary syndrome: Some studies have explored the pathophysiological roles of cytokines, such as interleukin-1β (IL-1β), interleukin-1 receptor antagonist (IL1Ra), interleukin-6 (IL-6), interleukin-17 (IL-17) and interleukin-18 (IL-18) in PCOS development (6, 7).