We gathered data comparing the clinical efficacy of the EFLL protocol, prolonged pituitary downregulation of the EFLL protocol and GnRH antagonist protocol before COH through collecting pregnancy rates and miscarriage rates per fresh transfer cycle, which are vital indicators for infertile couples (Vaegter et al., 2017; Veiga et al., 2020). Here, GNRH1 is linked to Infertility.