Studies by Tan et al. (2021) found that LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway (Tan et al., 2021), demonstrating that insulin signaling influences ovarian granulosa cell proliferation and differentiation through FOXO3 phosphorylation. This evidence concerns the gene SH2B3 and polycystic ovary syndrome.