MAPK3 and ischemia: When Hao et al. (2018) explored the effect of miR-1 on myocardial ischemia-reperfusion injury in rats pretreated with sevoflurane, he found that miR-1 was expressed at high levels in rats with ischemia-reperfusion, while MAPK3 was expressed at low levels, and excessive miR-1 expression or blockade of the PI3K pathway caused by silencing MAPK3 increased cell apoptosis, ischemia risk or infarct zone, and the concentration of lactate dehydrogenase.