Furthermore, the adipogenesis process also leads to inflammation and atrophy in muscle cells during obesity (Pellegrinelli et al., 2015), which explains an increase in the Cebpa, Tweak, and Nfkb, Atrogin1, and Murf1 mRNA levels simultaneously in the SFO-HF group. The gene discussed is CEBPA; the disease is obesity due to melanocortin 4 receptor deficiency.