Furthermore, the adipogenesis process also leads to inflammation and atrophy in muscle cells during obesity (Pellegrinelli et al., 2015), which explains an increase in the Cebpa, Tweak, and Nfkb, Atrogin1, and Murf1 mRNA levels simultaneously in the SFO-HF group. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.