Furthermore, the adipogenesis process also leads to inflammation and atrophy in muscle cells during obesity (Pellegrinelli et al., 2015), which explains an increase in the Cebpa, Tweak, and Nfkb, Atrogin1, and Murf1 mRNA levels simultaneously in the SFO-HF group. This evidence concerns the gene TNFSF12 and obesity due to melanocortin 4 receptor deficiency.