The contribution of the acid-sensing ion channels (ASICs) has been reported in an osteolysis-induced bone cancer pain (Nagae et al., 2007) and the protease-activator receptor 2 (PAR2) in peripheral neurons is the target of serine proteases and tryptase released from cancer cells to promote the prolonged mechanical allodynia in mouse cancer nociceptive models (Lam and Schmidt, 2010). The gene discussed is F2RL1; the disease is bone cancer.