ADRB3 and neoplasm: Moreover, propranolol and SR59230A were also able to reduce the tumor growth, confirming the crucial role of the β2-and β3-AR subtypes in sustaining pro-tumoral signaling in agreement with previous data obtained in other mouse models of cancer (Lamkin et al., 2012; Magnon et al., 2013; Calvani et al., 2019; Bruno et al., 2020; Calvani et al., 2020).