Combined with modern pharmacological study of RA disease treatment targets and the targets of WTD, the main KEGG pathways of WTD in the treatment of RA include the AGE-RAGE signaling pathway, PI3K-AKT signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, and HIF-1α signaling pathway. Here, PIK3CA is linked to rheumatoid arthritis.