The elevated NfL levels continued at the 3-month follow-up and seemed to return to normal at 15-month after stroke, indicating that levels of NfL could be a tool for monitoring infarct extent (Tiedt et al., 2018), predicting cognitive function (Peng et al., 2021; Wang J.H. et al., 2021) and mortality in patients with stroke (Gendron et al., 2020). This evidence concerns the gene NEFL and Stroke.