Recent studies demonstrated that blood ptau181 can predict cortical brain atrophy (Llibre-Guerra et al., 2019; Tissot et al., 2021), tau and amyloid-beta pathology (Lantero Rodriguez et al., 2020; Clark et al., 2021; Moscoso et al., 2021b), differentiate AD from other neurodegenerative diseases (Mielke et al., 2018; Thijssen et al., 2020; Grothe et al., 2021) and identify AD across the clinical continuum (Janelidze et al., 2020a; Karikari et al., 2020b, 2021). The gene discussed is MAPT; the disease is neurodegenerative disease.