The expression of Iba1+IL-4+ or Iba1+IL-10+ cells significantly increased in the Acupuncture group (average 20.8 for IL-4 and 21.0 for IL-10), compared to the Control (average 8.6 for IL-4 and 8.2 for IL-10), NS (average 8.8 for IL-4 and 8.8 for IL-10), and AD (average 10.6 for IL-4 and 9.2 for IL-10) groups in the DG area of the hippocampus (p < 0.01) (Figures 4C6–10, E6–10). Here, AIF1 is linked to Alzheimer disease.