Improvement in outcomes of the CNL group (39% of tumors) may be in combination with hormonal therapy and the PI3K/AKT/mTOR pathway inhibitor and for the CNH serous-like group (26% of tumors) treatment with cell cycle regulators and the PI3K/AKT/mTOR pathway inhibitors [19]. This evidence concerns the gene AKT1 and chronic neutrophilic leukemia.