ANGPTL8/betatrophin was enriched in LIHC as well as normal tissues (Supplementary Figure S6), significantly lower in BRCA, CHOL, bladder urothelial carcinoma (BLCA), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), uterine corpus endometrial carcinoma (UCEC), and significantly higher in colon adenocarcinoma (COAD), kidney renal clear cell carcinoma (KIRC), rectum adenocarcinoma (READ) than in normal tissues (Figure 2). The gene discussed is ANGPTL8; the disease is colon adenocarcinoma.