In the present study, we first analyzed the expression profiles of ANGPTL8/betatrophin using the HPA, GEPIA, DriverDBv3, ENCORI and UALCAN databases, and then based on the results comprehensively performed survival analyses in different cancer types via various databases including GEPIA, DriverDBv3, Kaplan Meier plotter and ENCORI. Here, ANGPTL8 is linked to cancer.