In addition, compared to that in the normal samples, ANGPTL8/betatrophin protein expression was significantly lower in ccRCC/KIRC samples from patients in cancer stage 1 and stage 3 (Supplementary Figure S7B), from Caucasian patients (Supplementary Figure S7C), from both males and females (Supplementary Figure S7D), from patients in the 21–40, 41–60 and 61–80 years old age groups (Supplementary Figure S7E), from patients in the extreme weight, obese and extreme obese categories (Supplementary Figure S7F), and from patients with tumor grade 2, grade 3 and grade 4 (Supplementary Figure S7G). This evidence concerns the gene ANGPTL8 and nonpapillary renal cell carcinoma.