Although the gene expression of ANGPTL8/betatrophin was significantly higher in ccRCC/KIRC patients than in normal samples, surprisingly, the protein expression levels of ANGPTL8/betatrophin in ccRCC/KIRC of different sample types, individual cancer stages, patient races, patient gender, patient age groups, patient weight categories, tumor grades were significantly lower than that in normal samples in the UALCAN database CPTAC samples. The gene discussed is ANGPTL8; the disease is nonpapillary renal cell carcinoma.