PPARGC1A and liver cancer: Although all of these studies used high concentration of DHA (50‐100 μmol/L), DHA increased mtDNA copy number and upregulated mRNA expression of genes associated with mitochondrial synthesis (PGC‐1α, NRF1, and TFAM) in mouse C2C12 myoblasts and human liver cancer cell line HepG237, 38 and reduced ROS content and increased mitochondrial membrane potential.38