Another well-known transcription factor complex that promotes cancer cell survival is nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), a family of transcription factors constituted by dimers of different combinations of 5 proteins sharing structural homology (NFKB1, NFKB2, RELA, RELB, and REL) [105]. The gene discussed is NFKB1; the disease is cancer.