In addition, considering the fact that tetraspanins contribute to multiple pathological processes that might be therapeutically targeted42, it seems that it is necessary to analyze a) the competency of CD63 as a single biomarker compared with the known markers or scoring systems, and b) the therapeutic role of CD63 for sepsis based on the use of anti-CD63 antibodies, tetraspanin-derived recombinant soluble extracellular loops, and RNA interference knockdown strategies. Here, CD63 is linked to Sepsis.