FOXM1 and diabetes mellitus: Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 technology was used to generate mice with partial deletions of the Ins1 and Ins2 promoters, and the results showed that only homozygous mice with mutations in the highly conserved GG2–GG1/A2 elements of the Ins1 and Ins2 promoters developed diabetes.