Our main hypothesis was that synaptic function measured with Ng, BACE1 and Ng/BACE1 ratio levels in LLD depends onthe status of AD biomarkers in LLD: LLD with normal AD biomarkers (LLD NoAD) would show Ng, BACE1 and Ng/BACE1 ratio levels similar to NC; LLD with signs of AD pathology (LLD AD) would show higher Ng, BACE1 and Ng/BACE1 levels than NC as is typical for AD. This evidence concerns the gene NRGN and Alzheimer disease.