Herein, we created a renal fibrosis model in an Ltbp4S−/− mouse in an attempt to investigate the mechanisms underlying LTBP4/TGFβ signalling and elucidate the impact of LTBP4 on the pathogenesis of renal tubular interstitial fibrosis (TIF). The gene discussed is TGFB1; the disease is renal fibrosis.