NOTCH1 and adenocarcinoma: The other genes that were much more mutated in SCC (with estimated mutation proportion in SCC and in adenocarcinoma, respectively) were LRP1B (23%, 10%), KMT2D (16%, 7%), FAT1 (15%, 5%), CDKN2A (12%, 2%), NOTCH1 (10%, 3%), and NFE2L2 (10% and 1%).