Although timely revascularization andpharmacological treatment with beta-blockers and ACE inhibitors can partiallymitigate the progression of post-MI adverse cardiac remodeling, these treatments dolittle to improve existing cardiac structural damage, and improving cardiacstructural damage is urgently needed to improve the replicative capacity ofcardiomyocytes after MI injury [1,22]. Here, ACE is linked to myocardial infarction.