In the present study, we hypothesized that GPR39 agonist, TC-G 1008, attenuates inflammation via sirtuin 1(SIRT1)/PPARG coactivator 1 alpha (PGC-1α)/nuclear factor, erythroid 2 like 2(Nrf2), leading to improvement of neurological function in a rat model of neonatal HIE. The gene discussed is SIRT1; the disease is perinatal asphyxia.