PKM and systemic lupus erythematosus: To better prove the correlation between microglial PKM2 upregulation and hippocampal neuron damage or cognitive dysfunction in lupus, AAV9-shPKM2 virus, targeting microglia, was stereotactically injected into the lateral ventricle of MRL/lpr mice to specifically downregulate PKM2 on microglia, after which morphological alterations of neurons in the hippocampus were examined, and hippocampus-dependent spatial learning and memory and contextual memory were also analyzed by MWM and fear-conditioning paradigm [109, 110].