In this study, the content of SPLUNC1 mRNA in lungs of Bbs was 4.71 times higher than that of Ahs in 4th-dpi group and the content of SPLUNC1 mRNA in lungs of Bbs was 9.72 times higher than that of Ahs in 14th-dpi group, which indicates that the resistance that Bbs possesses to Mo infection may be associated closely with the high expression of SPLUNC1 gene. The gene discussed is BPIFA1; the disease is infection.