Iorga Iorga A A Cunningham Cunningham CM CM Moazeni Moazeni S S Ruffenach Ruffenach G G Umar Umar S S Eghbali Eghbali M M The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy Biol Sex Differ Biol Sex Differ 2017 2017 8 8 1 1 33 33. Here, ESR1 is linked to cardiovascular disorder.