Arita Arita Y Y Kihara Kihara S S Ouchi Ouchi N N Takahashi Takahashi M M Maeda Maeda K K Miyagawa Miyagawa J J et al et al Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem Biophys Res Comm Biochem Biophys Res Comm 1999 1999 257 257 1 1 79 79 83 83 10092513 10092513. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.