Patel Patel VB VB Basu Basu R R Oudit Oudit GY GY ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity Adipocyte Adipocyte 2016 2016 5 5 3 3 306 306 311 311 27617176 27617176. The gene discussed is ANGPT1; the disease is obesity due to melanocortin 4 receptor deficiency.