Figure 4 demonstrated that sepsis group wasable to reduce Bcl-2 mRNA expression and promote Bax, caspase-3, VNN1, as wellas FoxO1 mRNA expression. By contrast, Atr III could enhance Bcl-2 mRNAexpression (P < 0.05/0.01). Concurrently, Atr III was ableto restrain Bax, caspase-3, VNN1, as well as FoxO1 mRNA expression, insepsis-mediated lung injury (P < 0.05/0.01). This evidence concerns the gene CASP3 and Sepsis.