For instance, miR-582-3p expression is remarkably downregulated in bone metastatic prostate cancer tissues, and miR-582-3p under-expression is linked to poor prognosis of the patients; miR-582-3p targets the TGF-β signaling pathway to impede cell migration, invasion, and bone metastasis of cancer cells (11). The gene discussed is TGFB1; the disease is Familial prostate cancer.