For example, circ_0084043, whose expression is remarkably upregulated in MM tissues, enhances MM cell proliferation, migration, and invasion by regulating the miR-153-3p/Snail axis (4); circ_0016418, whose expression is remarkably upregulated in MM tissues and cell lines, facilitates MM cell proliferation, migration, and epithelial-mesenchymal transition (EMT) by suppressing miR-625 expression and upregulating YY1 expression (5); and circ_0025039 facilitates MM cell proliferation, invasion, and glucose metabolism by modulating the miR-198/CDK4 axis (16). The gene discussed is CDK4; the disease is Miyoshi myopathy.