A meta-analysis by Jin et al. conducted showed that an MTHFR polymorphism, i.e., rs1801133 increases the risk of developing HCC, especially in European patients with chronic liver disease; in this meta-analysis, ten studies showed that compared to the CT genotype, the TT genotype increased the risk of developing HCC (8). The gene discussed is MTHFR; the disease is hepatocellular carcinoma.