In contrast, the MTHFR T allele (rs1801133) was associated with multinodular HCC at diagnosis, with an allele frequency of 0.33 for patients with multinodular tumors and 0.21 for patients with a uninodular tumor [p=0.040 OR 1.83 CI (1.02-3.29)]. Here, MTHFR is linked to neoplasm.