As lncRNA H19 and TET1 are both important regulatory factors in UFs (18), with lncRNA H19 expression acting as an estrogen receptor (ER) modulator and the plasma H19 levels being significantly correlated with the ER and progesterone receptor (PR) (19,20), we hypothesized that they are involved in the pathogenesis and postoperative recurrence of the disease. This evidence concerns the gene PGR and Ochoa syndrome.