By day 8, both genotypes cleared infection from the liver and serum (Matloubian et al., 1994; Figure 3SA; data not shown) and had comparable numbers and frequencies of NP396-specific CD8+ T cells (Figures S3B and S3C) with similar phenotypes, although there were slightly higher percentages of KLRG1+CD127− NP396-specific effector cells in the Pik3cdE1020K/+ mice (Figures S3D and S3E). This evidence concerns the gene CD8A and infection.