Physiological serum level of hepcidin was reported to be 2.3 nM, 7.8 nM and 6.5 nM for infants, male adults and female adults, respectively [41, 42], and the levels could be over 300 nM in critically ill patients with anemia and hemodialysis patients [43, 44]. The gene discussed is HAMP; the disease is anemia (phenotype).