PPP6R3 and obesity due to melanocortin 4 receptor deficiency: The risk of the composite outcome was significantly increased for class 1 obesity in the fully adjusted model (adjusted for age, sex, comorbidities and SAPS3) and doubled for class 2 and 3 obesity together (BMI≥ 35 kg/m2) in all the adjusted models, compared with the reference group (Table 3, Panel A).