MSH2 and cancer: In particular, we adopted the Hereditary Cancer Solution CE-IVD kit (SOPHiA Genetics, Saint-Sulpice, Switzerland), a NGS capture-based target enrichment of 26 cancer related genes (ATM, APC, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, FAM175A, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PALB2, PIK3CA, PMS2, PMS2C, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53, XRCC2).