In particular, we adopted the Hereditary Cancer Solution CE-IVD kit (SOPHiA Genetics, Saint-Sulpice, Switzerland), a NGS capture-based target enrichment of 26 cancer related genes (ATM, APC, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, FAM175A, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PALB2, PIK3CA, PMS2, PMS2C, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53, XRCC2). The gene discussed is CDH1; the disease is cancer.