To assess the extent of alterations in the neuroplasticity and neurogenesis in the dentate gyrus, DOX was administered in Wistar rats (2 mg/Kg/week, i.p) for 4 weeks and resulted in cognitive deficits accompanied by a decrease in the levels of BDNF and TrKB (tropomyosin-related kinase-B) (Park et al. 2018). The gene discussed is BDNF; the disease is Cognitive impairment.