AREG and epidermolysis bullosa simplex: A recent study has also shown that an increased autocrine activation of the amphiregulin (AREG)–EGFR pathway, signalling through Raf–ERK1/2 kinases, induces TSLP expression in keratin-deficient murine keratinocytes, and detectable levels of AREG and TSLP serum proteins have also been found in EBS patients, possibly contributing to itch and inflammation in these patients (Scheffschick et al., 2019).