Epidermolysis bullosa simplex (EBS) is a rare skin condition usually caused by mutations in the keratin intermediate filament proteins keratin 5 (K5, also known as KRT5) or keratin 14 (K14, also known as KRT14) (Bonifas et al., 1991; Coulombe et al., 1991; Lane et al., 1992), leading to skin blistering and wound development. Here, KRT5 is linked to epidermolysis bullosa simplex.