RYR2 and catecholaminergic polymorphic ventricular tachycardia: The hereditary pro-arrhythmic condition catecholaminergic polymorphic ventricular tachycardia (CPVT), is associated with gene mutations involving ryanodine receptor type 2 (RYR2), calsequestrin (CASQ2), triadin (TRDN) or calmodulin (CALM1, CALM2 and CALM3) [54].