In addition, knockdown of NLRP3 suppressed the mRNA and protein levels of IL‐1β and IL‐18 in both AR42J cells (Figure 5C, D) and its supernatants (Figure 5E, F), suggesting that targeting NLRP3‐mediated pyroptotic cell death was novel to attenuate STC‐induced AP progression in vitro. This evidence concerns the gene IL1B and alkaline phosphatase measurement.