The rs11085727-T allele of TYK2, a lead variant from the both critically ill and hospitalized COVID GWAS was associated with a reduced risk for psoriasis (OR = 0.88 [0.86– 0.91], P = 6.48 × 10−23), psoriatic arthropathy (OR = 0.82 [0.76 – 0.87], P = 6.97 × 10−12), and lupus (OR = 0.84 [0.76 – 0.91], P = 63.97 × 10−06). The gene discussed is TYK2; the disease is systemic lupus erythematosus.