Deletion of CRHR1 in Mor-Ens alleviated anxiety, depression, and impaired social interaction, while it did not affect conditioned aversion during opiate withdrawal (Fig. 6j–p), suggesting that CeA GABAergic and CRH connections with Mor-Ens might exert not exactly the same effects on negative effect. Here, CRHR1 is linked to depressive symptom measurement.