CD40LG and metabolic syndrome: We recently demonstrated that brown bears (Ursus arctos) which hibernate for 5–6 months during winter, gain weight considerably before hibernation, but despite kidney insufficiency, dyslipidemia and inactivity do not develop atherosclerosis or cardiovascular disease (CVD), have strikingly high levels of IgM and IgG1 anti-PC, thus a potential natural immunization against atherosclerosis33.