HLA-DRB5 and Alzheimer disease: In addition, KIF25 was found hypermethylated in AD23, HLA-DQB1 has alleles showing association to AD24,25, CHRM5, a cholinergic receptor, is up-regulated in AD26, HLA-DRB5 was identified as a risk gene for AD25, MTRNR2L12 has been proposed as a candidate blood marker of early AD-Like Dementia in adults with Down Syndrome27, and ADAMTS18 possesses secretase activity, a relevant feature in AD development/progression.