Though we did not find any differential expression of MAPT (microtubule associated protein tau) or APP (amyloid beta precursor protein), which gene products contribute to neurofibrillary tangles and Aβ plaque deposition in cortical AD layers, our data provide indications of layer specific modified expression of genes potentially affecting APP metabolism and Aβ generation. The gene discussed is MAPT; the disease is Alzheimer disease.