Consequently, we performed a case control study involving 161 SZ patients, 283 BD patients and 160 healthy controls (HC) in order to analyze: (i) the circulating levels of the sHLA-E isoform and its correlation with disease risk and patients clinical characteristics; and (ii) the distribution of the HLA-E*01:01 and HLA-E*01:03 genotypes and their potential correlation with sHLA-E levels. Here, HLA-E is linked to Behcet disease.