However, the fact that GYLN levels were marginally significantly higher in those with SOCs compared to those with non-severe reactions in our study might be due to the limited sample size, or the roles of GYLN in SOCs may be, in fact, not as important as that of S100A8/A9 in SJS/TEN. The gene discussed is IGKV1D-22; the disease is toxic epidermal necrolysis.