The substantial GLP-1 response to oral glucose tolerance tests (OGTTs) after RYGBP is thought to be involved in type-2 diabetes remission after RYGBP25, but this hypothesis was refuted by Mokadem et al.34, who reported similar responses to RYGBP in both wild-type mice and two nonfunctional GLP-1 mice (α-gustidin deficient and GLP1-receptor deficient). The gene discussed is GCG; the disease is type 2 diabetes mellitus.