However, in Dravet syndrome mouse model, failure of increased expression in function of Nav1.1 channels during physiologically decreased expression in Nav1.3 channels may lead to intractable seizures and various comorbidities, such as ataxia, sleep disorders, and autistic-like behaviors, and spatial learning and memory defects25,26. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.