Although the absence of literature data in this regard precludes the possibility to draw definitive conclusions, a possible pragmatical implication of these findings, if confirmed in future studies, is the possibility to strategically select the site of metastasis to be biopsied in order to maximize the opportunity of access to novel anti-HER2 drugs for patients originally classified as HER2-0 based on the primary tumor phenotype. This evidence concerns the gene ERBB2 and neoplasm.