FN1 and malignant colon neoplasm: Patients were also categorized according to first-line palliative treatment received and were grouped as (1) Fn enriched, FOLFIRI-treated colon cancer, (2) Fn negative, FOLFIRI-treated colon cancer, (3) Fn enriched, FOLFOX-treated colon cancer, and (4) Fn negative, FOLFOX-treated colon cancer (Supplementary Fig. S2A,B).