TLR2 and Parkinson disease: After CU-CPT22 treatment, accumulated p-α-syn and activated TLR2-mediated signaling were alleviated in CU-CPT22 + MPTP group when compared with MPTP group (Figs. 4 and 5), which was in consistent with our published study regarding the association between SCs and inflammatory cytokines in sural nerves of PD patients [14].