Consistent with the results in AML12 cells, K102R or K211R mutant protein level was significantly higher than that of wild-type C/EBPβ in SIRT2-KO murine livers (Fig. 7j), whereas the viral infection and transcription level were similarly indicated by BLI and qRT-PCR (data not shown). This evidence concerns the gene CEBPB and viral infectious disease.