The relative colony formation rate and migration ability of siCaM-treated TRPC1-overexpressed SW620 cells were markedly decreased to 75.8% and 65.8% of the TRPC1-transfected cells, respectively, demonstrating that CaM knockdown had attenuated the oncogenic effect of TRPC1 in CRC cells (Fig. 7B, C). Here, TRPC1 is linked to colorectal carcinoma.